| Jornada 1 | 29/08/2010 | RAYO VALLEC. | 3 | NUMANCIA | 2 |
| Jornada 2 | 05/09/2010 | CORDOBA | 2 | RAYO VALLEC. | 3 |
| Jornada 3 | 12/09/2010 | RAYO VALLEC. | 1 | TENERIFE | 0 |
| Jornada 4 | 19/09/2010 | GIMNASTIC | 0 | RAYO VALLEC. | 1 |
| Jornada 5 | 26/09/2010 | RAYO VALLEC. | 4 | HUESCA | 0 |
| Jornada 6 | 03/10/2010 | ALCORCON | 2 | RAYO VALLEC. | 0 |
| Jornada 7 | 10/10/2010 | RAYO VALLEC. | 3 | VILLARREAL B | 0 |
| Jornada 8 | 17/10/2010 | GRANADA | 1 | RAYO VALLEC. | 1 |
| Jornada 9 | 24/10/2010 | RAYO VALLEC. | 0 | RECREATIVO | 0 |
| Jornada 10 | 31/10/2010 | BETIS | 4 | RAYO VALLEC. | 0 |
| Jornada 11 | 07/11/2010 | RAYO VALLEC. | 3 | VALLADOLID | 0 |
| Jornada 12 | 14/11/2010 | ALBACETE | 1 | RAYO VALLEC. | 1 |
| Jornada 13 | 21/11/2010 | RAYO VALLEC. | 3 | PONFERRADINA | 1 |
| Jornada 14 | 28/11/2010 | LAS PALMAS | 2 | RAYO VALLEC. | 1 |
| Jornada 15 | 05/12/2010 | RAYO VALLEC. | 2 | GIRONA | 0 |
| Jornada 16 | 12/12/2010 | SALAMANCA | 0 | RAYO VALLEC. | 1 |
| Jornada 17 | 19/12/2010 | ELCHE | 1 | RAYO VALLEC. | 1 |
| Jornada 18 | 02/01/2011 | RAYO VALLEC. | 1 | CELTA | 3 |
| Jornada 19 | 09/01/2011 | XEREZ | 0 | RAYO VALLEC. | 1 |
| Jornada 20 | 16/01/2011 | RAYO VALLEC. | 3 | CARTAGENA | 1 |
| Jornada 21 | 23/01/2011 | BARCELONA B | 1 | RAYO VALLEC. | 2 |
| Jornada 22 | 30/01/2011 | NUMANCIA | 0 | RAYO VALLEC. | 3 |
| Jornada 23 | 06/02/2011 | RAYO VALLEC. | 4 | CORDOBA | 2 |
| Jornada 24 | 13/02/2011 | TENERIFE | 2 | RAYO VALLEC. | 1 |
| Jornada 25 | 20/02/2011 | RAYO VALLEC. | 1 | GIMNASTIC | 1 |
| Jornada 26 | 27/02/2011 | HUESCA | 4 | RAYO VALLEC. | 1 |
| Jornada 27 | 02/03/2011 | RAYO VALLEC. | 1 | ALCORCON | 0 |
| Jornada 28 | 06/03/2011 | VILLARREAL B | 1 | RAYO VALLEC. | 2 |
| Jornada 29 | 13/03/2011 | RAYO VALLEC. | 1 | GRANADA | 1 |
| Jornada 30 | 20/03/2011 | RECREATIVO | 1 | RAYO VALLEC. | 1 |
| Jornada 31 | 27/03/2011 | RAYO VALLEC. | 1 | BETIS | 0 |
| Jornada 32 | 03/04/2011 | VALLADOLID | 2 | RAYO VALLEC. | 2 |
| Jornada 33 | 10/04/2011 | RAYO VALLEC. | 3 | ALBACETE | 3 |
| Jornada 34 | 17/04/2011 | PONFERRADINA | 0 | RAYO VALLEC. | 1 |
| Jornada 35 | 24/04/2011 | RAYO VALLEC. | 2 | LAS PALMAS | 0 |
| Jornada 36 | 01/05/2011 | GIRONA | 1 | RAYO VALLEC. | 3 |
| Jornada 37 | 08/05/2011 | RAYO VALLEC. | 1 | SALAMANCA | 2 |
| Jornada 38 | 11/05/2011 | RAYO VALLEC. | 1 | ELCHE | 2 |
| Jornada 39 | 15/05/2011 | CELTA | 0 | RAYO VALLEC. | 0 |
| Jornada 40 | 22/05/2011 | RAYO VALLEC. | 3 | XEREZ | 0 |
| Jornada 41 | 29/05/2011 | CARTAGENA | 2 | RAYO VALLEC. | 4 |
| Jornada 42 | 05/06/2011 | RAYO VALLEC. | 2 | BARCELONA B | 3 |